Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.003 0.372 0.16 0.096
biological_process el 19 0.584 0.912 0.767 0.104
biological_process ka 19 0.001 0.367 0.145 0.096
biological_process rf 19 0.003 0.372 0.16 0.096
disease ct 9 0.035 0.697 0.353 0.242
disease el 9 0.113 0.918 0.478 0.272
disease ka 9 0.004 0.666 0.347 0.245
disease rf 9 0.034 0.697 0.354 0.243
genetic_interaction ct 17 0.0 0.975 0.544 0.31
genetic_interaction el 17 0.0 0.976 0.557 0.306
genetic_interaction ka 17 0.0 1.0 0.882 0.322
genetic_interaction rf 17 0.0 0.965 0.545 0.307
molecular_function ct 2 0.431 0.637 0.534 0.103
molecular_function el 2 0.406 0.658 0.532 0.126
molecular_function ka 2 0.456 0.638 0.547 0.091
molecular_function rf 2 0.431 0.637 0.534 0.103
pathway ct 19 0.001 0.901 0.491 0.299
pathway el 19 0.001 0.793 0.412 0.294
pathway ka 19 0.001 1.0 0.843 0.363
pathway rf 19 0.001 0.785 0.387 0.268
phenotype ct 7 0.007 0.609 0.402 0.25
phenotype el 7 0.085 0.561 0.32 0.181
phenotype ka 7 0.006 0.655 0.426 0.268
phenotype rf 7 0.007 0.609 0.402 0.25
protein_interaction ct 19 0.002 0.4 0.16 0.11
protein_interaction el 19 0.003 0.258 0.091 0.07
protein_interaction ka 19 0.008 1.0 0.74 0.435
protein_interaction rf 19 0.002 0.386 0.149 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 19 0.001 0.981 0.524 0.447
integration_mean_by_presence el 19 0.0 0.518 0.185 0.147
integration_mean_by_presence ka 19 0.0 0.499 0.226 0.159
integration_mean_by_presence rf 19 0.0 0.839 0.299 0.255
mean ct 19 0.0 0.983 0.53 0.448
mean el 19 0.0 0.346 0.107 0.108
mean ka 19 0.0 0.358 0.119 0.107
mean rf 19 0.0 0.392 0.146 0.129

CDF plots of non integrated kernels

CDF plots of integrated kernels